Mitochondrial stress signalling extends lifespan through a conserved nucleolar pathway
Elena Park, Samuel Okafor, Lin Wei & Hannah Moreau
Published 9 October 2026 · doi.org/10.5555/jc.2026.0412
Abstract
Mild mitochondrial stress extends lifespan in many species, but how the signal reaches the rest of the cell is unclear. Here we show that the mitochondrial unfolded protein response shrinks the nucleolus and lowers ribosome production in C. elegans, and that this step is required for the longer life of stressed animals.
Fig. 1 | Survival of control and mitochondrial-stress animals (n = 120 per group).
We find that nucleolar size predicts remaining lifespan in individual animals, and that the same pathway operates in mouse fibroblasts under comparable stress.
